[1]Bi W L,Parysek L M,Warnick R,et al.In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy[J].Human Gene Therapy,1993,4(6):725.

[2]Freeman S M,Abboud C N,Whartenby K A,et al.The“bystander effect”：tumor regression when a fraction of the tumor mass is genetically modified[J].Cancer Res,1993,53(21):5274.

[3]Mohr L.Hepatocellular carcinoma:novel therapeutic approaches[J].Schweiz Rundsch Mde Prax,2007,96(14):553.

[4]Lemken M L,Graepler F,Wolf C,et al.Fusion of HSV?1 VP22 to a bifunctional chimeric super CD suicide gene compensates for low suicide gene transduction efficiencies[J].Int J Oncol,2007,30(5):1153.

[5]孙春晓，何荣根.恶性肿瘤自杀基因治疗研究进展[J].实用肿瘤杂志,1999,14(4):255.

[6]杜标炎,徐勤,吴绍锋,等.六味地黄汤对糖皮质激素肾阴虚模型免疫器官淋巴细胞凋亡的抑制作用(Ⅰ)[J].广州中医药大学学报,2000,17(3):204.

[7]刘福君,茹祥斌.地黄及六味地黄汤(丸)的免疫药理及抗肿瘤作用[J].中草药,1996,27(2):116.

[8]宋丽丽,张瑜,张大禄.六味地黄方的免疫、抗肿瘤药理研究[J].中成药,2001,23(12):910.

[9]杜标炎,王慧峰,谭宇蕙,等.六味地黄丸对小鼠移植性肝癌自杀基因治疗的增效作用[J].广州中医药大学学报,2007,24(2):132.

[10]杜标炎,张爱娟,谭宇蕙,等.自杀基因系统联合六

味地黄丸对肝癌细胞杀伤的协同作用[J].广州中医药大学学报,2008,25(4):319.

[11]杜标炎,谭宇蕙,吴映雅,等.逆转录病毒载体介导HSV1?tk/GCV肿瘤自杀基因治疗系统的构建[J].广州中医药大学学报,2004,21(5):395.

[12]谭宇蕙,吴映雅,杜标炎,等.大鼠肝癌细胞HSV?tk/GCV自杀基因系统的构建及其旁观者效应[J].世界华人消化杂志,2005,13(17):2069.

[13]戴体俊.合并用药的定量分析[J].中国药理学通报,1998,14:479.

[14]刘为池,叶刚.自杀基因治疗旁观者效应研究进展[J].国外医学:泌尿系统分册,2000,20(增刊):121

精品学习网 医药卫生栏目